Depending on the needs, connect the ZD421 to existing wired and wireless networks, or directly to a PC. It is equipped with USB and a USB host, as well as Bluetooth Low Energy (BLE) and NFC, standard. Optionally, expand it to include Ethernet, serial, Wi-Fi 802.11ac and Bluetooth 4.1 interfaces. It is easy to operate via 3 buttons and the current printer status may be viewed at any time via five integrated LEDs. Plus, the movable media sensor ensures high compatibility as well as almost free media selection.

Additionally, Zebra has ensured that the ZD421 is transformable into a portable printer, if desired, for example via the optional carrying case. The convenient battery option provides enough power for an entire shift, reducing work steps and increases productivity. Plus, the printer's compact footprint also makes it easy to transport. The direct thermal model measures 220.8 x 177.5 x 150.7 mm (W x D x H) and weighs only 1.35 kg, while the thermal transfer model measures 267 x 202 x 189 mm (W x D x H) at 2.05 kg, and the ribbon cassette model 254 x 202 x 177 mm (W x D x H) with 2.3 kg.

The ZD421 is supported by the various tools of the Link-OS-based Zebra »Print DNA«. These include the »PrintSecure« security tool and the »Printer Profile Manager Enterprise« management tool.